InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sv2a

Summary

InnateDB Protein

IDBP-174743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sv2a

Protein Name

synaptic vesicle glycoprotein 2 a

Synonyms

AI746429; mKIAA0736;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037576

InnateDB Gene

IDBG-174739 (Sv2a)

Protein Structure

UniProt Annotation

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.Receptor for the botulinium neurotoxin type A/BOTA.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in conventional synapses and cone ribbon synapses in the retina (at protein level). {ECO:0000269PubMed:12687700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0006874	cellular calcium ion homeostasis
GO:0007268	synaptic transmission
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005911	cell-cell junction
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030672	synaptic vesicle membrane
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0045202	synapse
GO:0048786	presynaptic active zone

Protein Structure and Domains

PDB ID

MGI:1927139

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
IPR022308 Synaptic vesicle protein SV2

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIS5

PhosphoSite