Version 5.4
Homo sapiens Protein: TAX1BP3
Summary
InnateDB Protein IDBP-17476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAX1BP3
Protein Name Tax1 (human T-cell leukemia virus type I) binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000225525
InnateDB Gene IDBG-236056 (TAX1BP3)
Protein Structure
UniProt Annotation
Function May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269PubMed:10940294, ECO:0000269PubMed:16855024, ECO:0000269PubMed:21139582}.
Subcellular Localization Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
Disease Associations
Tissue Specificity Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes. {ECO:0000269PubMed:10940294, ECO:0000269PubMed:16855024}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032864 activation of Cdc42 GTPase activity
GO:2000009 negative regulation of protein localization to cell surface
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR017268 Tax1-binding protein 3
PFAM PF00595
PF13180
PRINTS
PIRSF PIRSF037712
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14907
PhosphoSite PhosphoSite-O14907
TrEMBL
UniProt Splice Variant
Entrez Gene 30851
UniGene
RefSeq NP_055419
HUGO HGNC:30684
OMIM
CCDS CCDS11032
HPRD 18160
IMGT
EMBL AF028823 AF168787 AF234997 AF277318 AK315408 BC023980 CH471108
GenPept AAB84248 AAF43104 AAG44368 AAH23980 AAK69111 BAG37800 EAW90491 EAW90492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca