Version 5.4
Mus musculus Protein: Gulo
Summary
InnateDB Protein IDBP-174776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gulo
Protein Name gulonolactone (L-) oxidase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060912
InnateDB Gene IDBG-174774 (Gulo)
Protein Structure
UniProt Annotation
Function Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L- ascorbate. {ECO:0000269PubMed:14962674}.
Subcellular Localization Microsome membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver. {ECO:0000269PubMed:14962674}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003885 D-arabinono-1,4-lactone oxidase activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
GO:0050105 L-gulonolactone oxidase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0009058 biosynthetic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1353434
InterPro IPR006094 FAD linked oxidase, N-terminal
IPR007173 D-arabinono-1,4-lactone oxidase
IPR010031 Sugar 1,4-lactone oxidase
IPR010032 FAD-linked oxidoreductase
IPR016166 FAD-binding, type 2
IPR023595 L-gulonolactone/D-arabinono-1,4-lactone oxidase
PFAM PF01565
PF04030
PRINTS
PIRSF PIRSF000136
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58710
PhosphoSite PhosphoSite-P58710
TrEMBL Q8JZZ1
UniProt Splice Variant
Entrez Gene 268756
UniGene Mm.26207
RefSeq NP_848862
MGI ID
MGI Symbol Gulo
OMIM
CCDS CCDS36958
HPRD
IMGT
EMBL AK077740 AK167460 AY453064 BC019856 BC028828 BC034835
GenPept AAH19856 AAH28828 AAH34835 AAR15891 BAC36988 BAE39545

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca