InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slk

Summary

InnateDB Protein

IDBP-174802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slk

Protein Name

STE20-like kinase (yeast)

Synonyms

9A2; AV021402; AW411554; Etk4; mKIAA0204; mSLK; SMAK; Stk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026043

InnateDB Gene

IDBG-174800 (Slk)

Protein Structure

UniProt Annotation

Function

Mediates apoptosis and actin stress fiber dissolution. {ECO:0000269PubMed:10611247}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10611247, ECO:0000269PubMed:9808774}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10611247, ECO:0000269PubMed:8346215, ECO:0000269PubMed:9808774}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:103241

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001943 UVR domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022165 Polo kinase kinase

PFAM

PF00069
PF07714
PF02151
PF12474

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt