InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dand5

Summary

InnateDB Protein

IDBP-174815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dand5

Protein Name

DAN domain family, member 5

Synonyms

Cerl-2; Cerr2; coco; Dte;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070057

InnateDB Gene

IDBG-174811 (Dand5)

Protein Structure

UniProt Annotation

Function

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. {ECO:0000269PubMed:15466485}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016015	morphogen activity

Biological Process

GO:0003140	determination of left/right asymmetry in lateral mesoderm
GO:0003281	ventricular septum development
GO:0003283	atrial septum development
GO:0007368	determination of left/right symmetry
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0038101	sequestering of nodal from receptor via nodal binding
GO:0061371	determination of heart left/right asymmetry
GO:1900108	negative regulation of nodal signaling pathway
GO:1900146	negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry