Version 5.4
Mus musculus Protein: Agbl4
Summary
InnateDB Protein IDBP-174824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agbl4
Protein Name ATP/GTP binding protein-like 4
Synonyms 4930578N11Rik; 4931433A01Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000079568
InnateDB Gene IDBG-174822 (Agbl4)
Protein Structure
UniProt Annotation
Function Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000269PubMed:17244818, ECO:0000269PubMed:21074048}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:17244818}.
Disease Associations
Tissue Specificity Expressed abundantly in testis, pituitary and brain and to a lower extent in eye, stomach, adrenal and kidney. In brain, expressed at low level in cerebellum as compared to cortex. {ECO:0000269PubMed:17244818, ECO:0000269PubMed:21074048}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
Biological Process
GO:0006508 proteolysis
GO:0035609 C-terminal protein deglutamylation
GO:0035610 protein side chain deglutamylation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1918244
InterPro IPR000834 Peptidase M14, carboxypeptidase A
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q09LZ8
PhosphoSite PhosphoSite-Q09LZ8
TrEMBL
UniProt Splice Variant
Entrez Gene 78933
UniGene Mm.461314
RefSeq NP_001041654
MGI ID
MGI Symbol Agbl4
OMIM
CCDS CCDS51263
HPRD
IMGT
EMBL AL627183 AL627347 AL627425 AL662829 AL669940 AL669959 AL669965 AL671895 DQ867039 DQ867040
GenPept ABI51958 ABI51959 CAM13964 CAM16884 CAM16953 CAM17710 CAM17858 CAM19669 CAM21591 CAM21666 CAO77734 CAO77735 CAO77917 CAO77918 CAO77919 CAO77920 CAO78077 CAO78078 CAO78120 CAO78121 CAP19221 CAP19222 CAQ11260 CAQ11261 CAQ13050 CAQ13051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca