Version 5.4
Mus musculus Protein: Gadd45gip1
Summary
InnateDB Protein IDBP-174840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gadd45gip1
Protein Name growth arrest and DNA-damage-inducible, gamma interacting protein 1
Synonyms 2310040G17Rik; AI425883; Crif1; MRP-L59; Plinp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000037783
InnateDB Gene IDBG-174838 (Gadd45gip1)
Protein Structure
UniProt Annotation
Function Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1914947
InterPro IPR018472 Growth arrest/ DNA-damage-inducible protein-interacting protein 1
PFAM PF10147
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR59
PhosphoSite PhosphoSite-Q9CR59
TrEMBL
UniProt Splice Variant
Entrez Gene 102060
UniGene Mm.489649
RefSeq NP_899202
MGI ID
MGI Symbol Gadd45gip1
OMIM
CCDS CCDS22478
HPRD
IMGT
EMBL AK002738 AK003314 AK009723 AK019570 AK028227 BC061069
GenPept AAH61069 BAB22318 BAB22710 BAB26464 BAB31797 BAC25826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca