InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf16

Summary

InnateDB Protein

IDBP-174862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf16

Protein Name

Kruppel-like factor 16

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048825

InnateDB Gene

IDBG-174860 (Klf16)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

High expression in brain; olfactory tubercle, olfactory bulb, nucleus accumbens, striatum, hippocampal CA1 region, amygdala, dentate gyrus and frontal cortex. Moderate expression in hippocampal CA2-3 regions, piriform cortex, septum, and distinct thalamic nuclei. Low expression in the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007212	dopamine receptor signaling pathway