Version 5.4
Mus musculus Protein: Alg10b
Summary
InnateDB Protein IDBP-174897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alg10b
Protein Name asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097882
InnateDB Gene IDBG-174895 (Alg10b)
Protein Structure
UniProt Annotation
Function Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015459 potassium channel regulator activity
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2146159
InterPro IPR016900 Glucosyltransferase Alg10
PFAM PF04922
PRINTS
PIRSF PIRSF028810
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UGP8
PhosphoSite PhosphoSite-Q3UGP8
TrEMBL Q3UPY7
UniProt Splice Variant
Entrez Gene 380959
UniGene
RefSeq NP_001028613
MGI ID
MGI Symbol Alg10b
OMIM
CCDS CCDS27757
HPRD
IMGT
EMBL AK143038 AK147821 AK166344
GenPept BAE25257 BAE28159 BAE38718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca