InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hist2h2be

Summary

InnateDB Protein

IDBP-174912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hist2h2be

Protein Name

histone cluster 2, H2be

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088287

InnateDB Gene

IDBG-174910 (Hist2h2be)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006334	nucleosome assembly
GO:0019731	antibacterial humoral response
GO:0050830	defense response to Gram-positive bacterium