InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stap1

Summary

InnateDB Protein

IDBP-174975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stap1

Protein Name

signal transducing adaptor family member 1

Synonyms

AI586015; Brdg1; STAP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031171

InnateDB Gene

IDBG-174973 (Stap1)

Protein Structure

UniProt Annotation

Function

May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells. {ECO:0000269PubMed:10679268}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000305}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression restricted to the bone marrow. {ECO:0000269PubMed:10679268}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0030099	myeloid cell differentiation