InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Galnt3

Summary

InnateDB Protein

IDBP-174990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galnt3

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028378

InnateDB Gene

IDBG-174988 (Galnt3)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Glycosylates FGF23 (By similarity). Probably glycosylates fibronectin in vivo. May be involved in phosphate homeostasis. {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the reproductive tract, principally in the testis and uterus, and to a lesser degree in the cervix with only trace levels in the ovary. Also expressed at high level in sublingual gland, stomach and colon, with more moderate amounts present in the submandibular and parotid gland as well as the kidney. {ECO:0000269PubMed:8912633}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005509	calcium ion binding
GO:0030145	manganese ion binding

Biological Process

GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm