Version 5.4
Homo sapiens Protein: IMPACT
Summary
InnateDB Protein IDBP-1750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPACT
Protein Name Impact homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000284202
InnateDB Gene IDBG-1748 (IMPACT)
Protein Structure
UniProt Annotation
Function Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=May be associated with polysomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in brain. {ECO:0000269PubMed:11116084, ECO:0000269PubMed:11244491}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006446 regulation of translational initiation
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001498 Impact, N-terminal
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR020568 Ribosomal protein S5 domain 2-type fold
PFAM PF01205
PF05773
PRINTS
PIRSF
SMART SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2X3
PhosphoSite PhosphoSite-Q9P2X3
TrEMBL J3KT25
UniProt Splice Variant
Entrez Gene 55364
UniGene Hs.731692
RefSeq NP_060909
HUGO HGNC:20387
OMIM 615319
CCDS CCDS11886
HPRD 13739
IMGT
EMBL AB026264 AC007922 AC020937 AF208694 AF232229 AK292533 BC034016 BC036074 CH471088
GenPept AAG23917 AAG35736 AAH34016 AAH36074 BAA95160 BAF85222 EAX01186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca