Version 5.4
Homo sapiens Protein: SUMF2
Summary
InnateDB Protein IDBP-17500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUMF2
Protein Name sulfatase modifying factor 2
Synonyms pFGE;
Species Homo sapiens
Ensembl Protein ENSP00000275607
InnateDB Gene IDBG-17498 (SUMF2)
Protein Structure
UniProt Annotation
Function Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269PubMed:12757706, ECO:0000269PubMed:15708861, ECO:0000269PubMed:15962010}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000269PubMed:15708861, ECO:0000269PubMed:15962010}.
Disease Associations
Tissue Specificity Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta. {ECO:0000269PubMed:15708861, ECO:0000269PubMed:15962010}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR005532 Formylglycine-generating sulphatase enzyme domain
IPR016187 C-type lectin fold
PFAM PF03781
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBJ7
PhosphoSite PhosphoSite-Q8NBJ7
TrEMBL A0A024RDK8
UniProt Splice Variant
Entrez Gene 25870
UniGene Hs.279696
RefSeq NP_001139805
HUGO HGNC:20415
OMIM 607940
CCDS CCDS55111
HPRD 06400
IMGT
EMBL AK075477 AK300488 AK301627 AL050037 AY323911 AY359103 BC000224 BC006159 BC015600 BC084539 BC111092 CH471140
GenPept AAH00224 AAH06159 AAH15600 AAH84539 AAI11093 AAP86218 AAQ89461 BAC11643 BAG62203 BAG63112 CAB43247 EAX07980 EAX07982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca