Version 5.4
Mus musculus Protein: Slc36a1
Summary
InnateDB Protein IDBP-175001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc36a1
Protein Name solute carrier family 36 (proton/amino acid symporter), member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020499
InnateDB Gene IDBG-174999 (Slc36a1)
Protein Structure
UniProt Annotation
Function Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid. {ECO:0000269PubMed:11959859}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in small intestine, colon, kidney and brain. {ECO:0000269PubMed:11959859}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0015180 L-alanine transmembrane transporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0015193 L-proline transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0015808 L-alanine transport
GO:0015816 glycine transport
GO:0015824 proline transport
GO:0015992 proton transport
GO:0035524 proline transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2445299
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4D3
PhosphoSite PhosphoSite-
TrEMBL Q5F228
UniProt Splice Variant
Entrez Gene 215335
UniGene Mm.409096
RefSeq
MGI ID
MGI Symbol Slc36a1
OMIM
CCDS CCDS36156
HPRD
IMGT
EMBL AF453743 AL713870 AY211262 BC138556 BC138558 CH466575
GenPept AAI38557 AAI38559 AAM80480 AAO37090 EDL33496 EDL33497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca