InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fat2

Summary

InnateDB Protein

IDBP-175079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fat2

Protein Name

FAT tumor suppressor homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067556

InnateDB Gene

IDBG-175077 (Fat2)

Protein Structure

UniProt Annotation

Function

Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0010631	epithelial cell migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2685369

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like

PFAM

PF00008
PF00054
PF02210
PF07645
PF00028

PRINTS

PR00205

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179
SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt