InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptk2b

Summary

InnateDB Protein

IDBP-175130.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ptk2b

Protein Name

PTK2 protein tyrosine kinase 2 beta

Synonyms

CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PYK2; Raftk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086661

InnateDB Gene

IDBG-175126 (Ptk2b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005856	cytoskeleton
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

MGI:104908

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR011009 Protein kinase-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF03623
PF00373

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt