InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Neu1

Summary

InnateDB Protein

IDBP-175210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neu1

Protein Name

neuraminidase 1

Synonyms

AA407268; AA407316; Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu; Neu-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007253

InnateDB Gene

IDBG-175208 (Neu1)

Protein Structure

UniProt Annotation

Function

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269PubMed:9363440, ECO:0000269PubMed:9384611}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:9384611}; Peripheral membrane protein {ECO:0000269PubMed:9384611}; Lumenal side {ECO:0000269PubMed:9384611}. Lysosome lumen {ECO:0000269PubMed:9384611}. Cell membrane {ECO:0000269PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.

Disease Associations

Tissue Specificity

Highly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269PubMed:9384611}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004308	exo-alpha-sialidase activity
GO:0005515	protein binding
GO:0052794	exo-alpha-(2->3)-sialidase activity
GO:0052795	exo-alpha-(2->6)-sialidase activity
GO:0052796	exo-alpha-(2->8)-sialidase activity

Biological Process

GO:0009313	oligosaccharide catabolic process
GO:0016042	lipid catabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome