InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn1a

Summary

InnateDB Protein

IDBP-175213.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Scn1a

Protein Name

sodium channel, voltage-gated, type I, alpha

Synonyms

B230332M13; Nav1.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092558

InnateDB Gene

IDBG-175211 (Scn1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity

Biological Process

GO:0001508	action potential
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007628	adult walking behavior
GO:0019227	neuronal action potential propagation
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0050884	neuromuscular process controlling posture
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030315	T-tubule
GO:0030424	axon
GO:0033268	node of Ranvier
GO:0034706	sodium channel complex
GO:0043025	neuronal cell body
GO:0043194	axon initial segment

Protein Structure and Domains

PDB ID

MGI:98246

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008051 Voltage gated sodium channel, alpha-1 subunit
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR024583 Domain of unknown function DUF3451

PFAM

PF00520
PF06512
PF08016
PF11933

PRINTS

PR00170
PR01433
PR01664

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q68V28

UniProt Splice Variant

Entrez Gene

20265

UniGene

Mm.439704

RefSeq

MGI ID

MGI Symbol

Scn1a

OMIM

CCDS

HPRD

IMGT

EMBL

AJ810515 AL844526 AL928726

GenPept

CAH17959