InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcgr1

Summary

InnateDB Protein

IDBP-175239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcgr1

Protein Name

Fc receptor, IgG, high affinity I

Synonyms

AI323638; AV092959; CD64; FcgammaRI; IGGHAFC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029748

InnateDB Gene

IDBG-175237 (Fcgr1)

Protein Structure

UniProt Annotation

Function

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269PubMed:11911823, ECO:0000269PubMed:11911824}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G. {ECO:0000250}.

Disease Associations

Tissue Specificity

Macrophage-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019770	IgG receptor activity
GO:0019864	IgG binding

Biological Process

GO:0001788	antibody-dependent cellular cytotoxicity
GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001805	positive regulation of type III hypersensitivity
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0007166	cell surface receptor signaling pathway
GO:0009617	response to bacterium
GO:0019884	antigen processing and presentation of exogenous antigen
GO:0038094	Fc-gamma receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0050766	positive regulation of phagocytosis
GO:0050776	regulation of immune response