InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jag2

Summary

InnateDB Protein

IDBP-175256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jag2

Protein Name

jagged 2

Synonyms

D12Ggc2e; mJagged2-1; Serh; sm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075224

InnateDB Gene

IDBG-175254 (Jag2)

Protein Structure

UniProt Annotation

Function

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK- old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression. {ECO:0000269PubMed:9315665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0001709	cell fate determination
GO:0003016	respiratory system process
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007605	sensory perception of sound
GO:0009912	auditory receptor cell fate commitment
GO:0016331	morphogenesis of embryonic epithelium
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030217	T cell differentiation
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042492	gamma-delta T cell differentiation
GO:0045061	thymic T cell selection
GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1098270

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR006552 VWC out
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QYE5