InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hexb

Summary

InnateDB Protein

IDBP-175278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hexb

Protein Name

hexosaminidase B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022169

InnateDB Gene

IDBG-175276 (Hexb)

Protein Structure

UniProt Annotation

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563	beta-N-acetylhexosaminidase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0005975	carbohydrate metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006689	ganglioside catabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0007040	lysosome organization
GO:0007338	single fertilization
GO:0007341	penetration of zona pellucida
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008049	male courtship behavior
GO:0008360	regulation of cell shape
GO:0008654	phospholipid biosynthetic process
GO:0009313	oligosaccharide catabolic process
GO:0019915	lipid storage
GO:0019953	sexual reproduction
GO:0030203	glycosaminoglycan metabolic process
GO:0031323	regulation of cellular metabolic process
GO:0042552	myelination
GO:0043615	astrocyte cell migration
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048477	oogenesis
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005764	lysosome
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96074

InterPro

IPR015882 Beta-hexosaminidase, bacteial type, N-terminal
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase, superfamily
IPR025705 Beta-hexosaminidase
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like

PFAM

PF02838
PF00728

PRINTS

PR00738

PIRSF

PIRSF001093

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt