InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mknk2

Summary

InnateDB Protein

IDBP-175281.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mknk2

Protein Name

MAP kinase-interacting serine/threonine kinase 2

Synonyms

2010016G11Rik; Gprk7; Mnk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003433

InnateDB Gene

IDBG-175279 (Mknk2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269PubMed:11154262, ECO:0000269PubMed:17689282, ECO:0000269PubMed:17903173, ECO:0000269PubMed:20574055, ECO:0000269PubMed:20823271, ECO:0000269PubMed:20927323, ECO:0000269PubMed:9155017}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain. {ECO:0000269PubMed:9155017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030097	hemopoiesis
GO:0035556	intracellular signal transduction
GO:0071243	cellular response to arsenic-containing substance
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:894279

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt