Mus musculus Protein: Tmprss11d | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-175321.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Tmprss11d | ||||||
Protein Name | transmembrane protease, serine 11d | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000031175 | ||||||
InnateDB Gene | IDBG-175319 (Tmprss11d) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC. {ECO:0000250, ECO:0000269PubMed:24227843}. | ||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Transmembrane protease serine 11D catalytic chain: Secreted {ECO:0000250}. Note=Activated by cleavage and secreted. {ECO:0000250}. | ||||||
Disease Associations | |||||||
Tissue Specificity | Highly expressed in the esophagus, tongue, and trachea, low expression was seen in heart, lung, and adrenal gland. Isoform 2 is also highly expressed in the adrenal gland. {ECO:0000269PubMed:14691009}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2385221 | ||||||
InterPro |
IPR000082
SEA domain IPR001254 Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain IPR015420 Peptidase S1A, nudel IPR017329 Peptidase S1A, HAT/DESC1 |
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PFAM |
PF01390
PF00089 PF09342 |
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PRINTS |
PR00722
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PIRSF |
PIRSF037941
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SMART |
SM00200
SM00020 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q8VHK8 | ||||||
PhosphoSite | PhosphoSite- | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 231382 | ||||||
UniGene | Mm.422376 | ||||||
RefSeq | NP_663536 | ||||||
MGI ID | 2E7V | ||||||
MGI Symbol | Tmprss11d | ||||||
OMIM | |||||||
CCDS | CCDS39124 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AB053953 AF448809 AF539752 BC020151 | ||||||
GenPept | AAH20151 AAL47139 AAP97729 BAD89353 | ||||||