InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn9a

Summary

InnateDB Protein

IDBP-175340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn9a

Protein Name

sodium channel, voltage-gated, type IX, alpha

Synonyms

mKIAA4197; Nav1.7; PN1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097642

InnateDB Gene

IDBG-175350 (Scn9a)

Protein Structure

UniProt Annotation

Function

Plays a role in pain mechanisms, especially in the development of inflammatory pain. {ECO:0000269PubMed:15314237}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0031402	sodium ion binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006954	inflammatory response
GO:0009636	response to toxic substance
GO:0009791	post-embryonic development
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0048266	behavioral response to pain
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107636

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR024583 Domain of unknown function DUF3451

PFAM

PF00612
PF00520
PF06512
PF08016
PF11933

PRINTS

PR00170
PR01433

PIRSF

SMART

SM00015

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt