Version 5.4
Mus musculus Protein: Tmprss11a
Summary
InnateDB Protein IDBP-175349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmprss11a
Protein Name transmembrane protease, serine 11a
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000098634
InnateDB Gene IDBG-175347 (Tmprss11a)
Protein Structure
UniProt Annotation
Function Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:2684853
InterPro IPR000082 SEA domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017329 Peptidase S1A, HAT/DESC1
PFAM PF01390
PF00089
PRINTS PR00722
PIRSF PIRSF037941
SMART SM00200
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UQ41
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 194597
UniGene Mm.468426
RefSeq NP_001028405
MGI ID
MGI Symbol Tmprss11a
OMIM
CCDS CCDS51531
HPRD
IMGT
EMBL AK142820
GenPept BAE25202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca