InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim35

Summary

InnateDB Protein

IDBP-175376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim35

Protein Name

tripartite motif-containing 35

Synonyms

0710005M05Rik; A430106H13Rik; AW046487; HLS5; Mair; mKIAA1098; NC8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022623

InnateDB Gene

IDBG-175374 (Trim35)

Protein Structure

UniProt Annotation

Function

May play a role as a tumor suppressor. Implicated in the cell death mechanism. {ECO:0000269PubMed:12692137, ECO:0000269PubMed:14662771}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in brain, heart, kidney, spleen, skeletal muscle, lung and thymus. Lower expression found in stomach, large intestine and bone marrow. {ECO:0000269PubMed:12692137, ECO:0000269PubMed:14662771}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response
GO:0045930	negative regulation of mitotic cell cycle
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914104

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt