InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xirp2

Summary

InnateDB Protein

IDBP-175486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xirp2

Protein Name

xin actin-binding repeat containing 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028410

InnateDB Gene

IDBG-175484 (Xirp2)

Protein Structure

UniProt Annotation

Function

Protects actin filaments from depolymerization. {ECO:0000250}.

Subcellular Localization

Cell junction {ECO:0000269PubMed:17766470}. Note=Colocalizes with actin stress fibers.

Disease Associations

Tissue Specificity

Expression is restricted to heart and skeletal muscle. Present in intercalated disks of the heart and in the Z- disk region of skeletal muscle (at protein level). {ECO:0000269PubMed:17046827, ECO:0000269PubMed:17766470}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0003281	ventricular septum development
GO:0030036	actin cytoskeleton organization
GO:0045216	cell-cell junction organization
GO:0055008	cardiac muscle tissue morphogenesis