InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nmur2

Summary

InnateDB Protein

IDBP-175492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nmur2

Protein Name

neuromedin U receptor 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044718

InnateDB Gene

IDBG-175490 (Nmur2)

Protein Structure

UniProt Annotation

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues. {ECO:0000269PubMed:12217421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001607	neuromedin U receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005525	GTP binding
GO:0008188	neuropeptide receptor activity
GO:0042924	neuromedin U binding

Biological Process

GO:0002023	reduction of food intake in response to dietary excess
GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007417	central nervous system development
GO:0007625	grooming behavior
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling
GO:0048016	inositol phosphate-mediated signaling
GO:0048265	response to pain
GO:0050482	arachidonic acid secretion
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2441765

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005390 Neuromedin U receptor
IPR005392 Neuromedin U receptor, type 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10320
PF10324

PRINTS

PR00237
PR01565
PR01567

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BZ39