Version 5.4
Mus musculus Protein: Gm12824
Summary
InnateDB Protein IDBP-175509.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gm12824
Protein Name predicted gene 12824
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000092494
InnateDB Gene IDBG-175507 (Gm12824)
Protein Structure
UniProt Annotation
Function Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:23152936}; Single-pass type I membrane protein {ECO:0000269PubMed:23152936}.
Disease Associations
Tissue Specificity Highly expressed in heart and kidney. Also found in white and brown adipose tissue. {ECO:0000269PubMed:23152936}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0016055 Wnt signaling pathway
GO:0018158 protein oxidation
GO:0030178 negative regulation of Wnt signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0031301 integral component of organelle membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:3650152
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B1ATG9
PhosphoSite PhosphoSite-B1ATG9
TrEMBL
UniProt Splice Variant
Entrez Gene 666048
UniGene Mm.331779
RefSeq NP_001079018
MGI ID
MGI Symbol Trabd2b
OMIM
CCDS CCDS38843
HPRD
IMGT
EMBL AL646006 AL670175
GenPept CAM16094 CAM20425

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca