InnateDB Protein
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IDBP-17563.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FRYL
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Protein Name
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FRY-like
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000351113
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InnateDB Gene
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IDBG-17559 (FRYL)
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Protein Structure
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Function |
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269PubMed:16061630}.
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Subcellular Localization |
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Disease Associations |
Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
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Tissue Specificity |
Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin. {ECO:0000269PubMed:16061630}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O94915
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PhosphoSite |
PhosphoSite-O94915
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
285527
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UniGene |
Hs.595553
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RefSeq |
NP_055845
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HUGO |
HGNC:29127
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OMIM |
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CCDS |
CCDS43227
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HPRD |
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IMGT |
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EMBL |
AB020633
AC068037
AC096952
AL137546
BC021803
U80082
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GenPept |
AAD00351
AAH21803
BAA74849
CAB70804
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