InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsto1

Summary

InnateDB Protein

IDBP-175654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsto1

Protein Name

glutathione S-transferase omega 1

Synonyms

AA407097; AI194287; AU018802; GSTO 1-1; GSTX; p28; SPG-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026050

InnateDB Gene

IDBG-175652 (Gsto1)

Protein Structure

UniProt Annotation

Function

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0045174	glutathione dehydrogenase (ascorbate) activity
GO:0050610	methylarsonate reductase activity

Biological Process

GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019852	L-ascorbic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0055114	oxidation-reduction process
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071243	cellular response to arsenic-containing substance

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1342273

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR005442 Glutathione S-transferase, omega-class
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM