InnateDB Protein
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IDBP-17568.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KLRG1
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Protein Name
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killer cell lectin-like receptor subfamily G, member 1
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Synonyms
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2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349477
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InnateDB Gene
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IDBG-17564 (KLRG1)
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Protein Structure
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Function |
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269PubMed:19604491}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269PubMed:19604491}.
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Disease Associations |
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Tissue Specificity |
Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269PubMed:15879103, ECO:0000269PubMed:9842918}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q96E93
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PhosphoSite |
PhosphoSite-Q96E93
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TrEMBL |
F5H8E3
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UniProt Splice Variant |
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Entrez Gene |
10219
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UniGene |
Hs.558446
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RefSeq |
NP_005801
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HUGO |
HGNC:6380
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OMIM |
604874
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CCDS |
CCDS8599
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HPRD |
16076
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IMGT |
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EMBL |
AC006581
AF034952
AF081675
AF097358
AK316337
BC012621
CH471116
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GenPept |
AAC32200
AAC34731
AAD03719
AAH12621
BAH14708
EAW88594
EAW88595
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