InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsto2

Summary

InnateDB Protein

IDBP-175718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsto2

Protein Name

glutathione S-transferase omega 2

Synonyms

1700020F09Rik; 4930425C18Rik; GSTO 2-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052592

InnateDB Gene

IDBG-175714 (Gsto2)

Protein Structure

UniProt Annotation

Function

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0045174	glutathione dehydrogenase (ascorbate) activity
GO:0050610	methylarsonate reductase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0019852	L-ascorbic acid metabolic process
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1915464

InterPro

IPR002109 Glutaredoxin
IPR004045 Glutathione S-transferase, N-terminal
IPR005442 Glutathione S-transferase, omega-class
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM