InnateDB Protein
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IDBP-17580.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WHSC1L1
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Protein Name
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Wolf-Hirschhorn syndrome candidate 1-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313410
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InnateDB Gene
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IDBG-17572 (WHSC1L1)
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Protein Structure
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Function |
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269PubMed:16682010}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
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Disease Associations |
Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
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Tissue Specificity |
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. {ECO:0000269PubMed:11374904}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000313
PWWP domain
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PFAM |
PF00855
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PRINTS |
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PIRSF |
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SMART |
SM00293
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BZ95
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PhosphoSite |
PhosphoSite-Q9BZ95
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TrEMBL |
E9PQ95
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UniProt Splice Variant |
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Entrez Gene |
54904
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UniGene |
Hs.722308
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RefSeq |
NP_060248
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HUGO |
HGNC:12767
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OMIM |
607083
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CCDS |
CCDS6105
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HPRD |
06155
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IMGT |
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EMBL |
AC087362
AC087623
AF255649
AF332468
AF332469
AJ295990
AJ295991
AJ295992
AK000360
AK022560
AK127594
BC012059
BC062631
BC101717
BC107734
BC113469
BC115006
BC143510
CH471080
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GenPept |
AAG44637
AAH12059
AAH62631
AAI01718
AAI07735
AAI13470
AAI15007
AAI43511
AAK00354
AAK00355
BAA91110
BAB14099
CAC28350
CAC28351
CAC28352
EAW63320
EAW63321
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