InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHKG1

Summary

InnateDB Protein

IDBP-17588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHKG1

Protein Name

phosphorylase kinase, gamma 1 (muscle)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297373

InnateDB Gene

IDBG-17586 (PHKG1)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004689	phosphorylase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0050321	tau-protein kinase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0005980	glycogen catabolic process
GO:0006006	glucose metabolic process
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002291 Phosphorylase kinase, gamma catalytic subunit
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109
PR01049

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt