Version 5.4
Mus musculus Protein: Ugt2a3
Summary
InnateDB Protein IDBP-175889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ugt2a3
Protein Name UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms 2010321J07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000031195
InnateDB Gene IDBG-175887 (Ugt2a3)
Protein Structure
UniProt Annotation
Function UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in liver, with lower levels in duodenum and jejunum. {ECO:0000269PubMed:17050650}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
GO:0030259 lipid glycosylation
GO:0052695 cellular glucuronidation
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919344
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235 Glycosyl transferase, family 28, C-terminal
PFAM PF00201
PF04101
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BWQ1
PhosphoSite PhosphoSite-Q8BWQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 72094
UniGene Mm.482739
RefSeq NP_082370
MGI ID
MGI Symbol Ugt2a3
OMIM
CCDS CCDS19387
HPRD
IMGT
EMBL AK008601 AK050327 BC025795
GenPept AAH25795 BAB25770 BAC34191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca