Version 5.4
| Mus musculus Protein: Tnpo2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-176174.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tnpo2 | ||||||||
| Protein Name | transportin 2 (importin 3, karyopherin beta 2b) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000091051 | ||||||||
| InnateDB Gene | IDBG-176172 (Tnpo2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2384849 | ||||||||
| InterPro |
IPR000357
HEAT IPR001494 Importin-beta, N-terminal domain IPR016024 Armadillo-type fold |
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| PFAM |
PF02985
PF03810 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00913
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q99LG2 | ||||||||
| PhosphoSite | PhosphoSite-Q99LG2 | ||||||||
| TrEMBL | E9PV58 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 212999 | ||||||||
| UniGene | Mm.471720 | ||||||||
| RefSeq | NP_663365 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tnpo2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS22491 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC163703 AK029774 BC003275 | ||||||||
| GenPept | AAH03275 BAC26611 | ||||||||