InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tipin

Summary

InnateDB Protein

IDBP-176194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tipin

Protein Name

timeless interacting protein

Synonyms

1110005A05Rik; 1110018P21Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034964

InnateDB Gene

IDBG-176192 (Tipin)

Protein Structure

UniProt Annotation

Function

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269PubMed:17141802}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12875843}. Nucleus {ECO:0000269PubMed:12875843}.

Disease Associations

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:12875843}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000077	DNA damage checkpoint
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0008284	positive regulation of cell proliferation
GO:0009411	response to UV
GO:0031573	intra-S DNA damage checkpoint
GO:0044770	cell cycle phase transition
GO:0048478	replication fork protection