InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jsrp1

Summary

InnateDB Protein

IDBP-176197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jsrp1

Protein Name

junctional sarcoplasmic reticulum protein 1

Synonyms

2300003C06Rik; 2310032K21Rik; JP-45; JP45;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020435

InnateDB Gene

IDBG-176195 (Jsrp1)

Protein Structure

UniProt Annotation

Function

Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000250, ECO:0000269PubMed:16423849, ECO:0000269PubMed:16638807}.

Subcellular Localization

Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes.

Disease Associations

Tissue Specificity

Specifically expressed in skeletal muscle. Detected in skeletal muscle and tongue (at protein level). {ECO:0000269PubMed:12871958}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0072657	protein localization to membrane