InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itm2c

Summary

InnateDB Protein

IDBP-176285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itm2c

Protein Name

integral membrane protein 2C

Synonyms

3110038L02Rik; BRI3; Bricd2c; E25; E25C; ITM3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027425

InnateDB Gene

IDBG-176283 (Itm2c)

Protein Structure

UniProt Annotation

Function

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. {ECO:0000269PubMed:14592447}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:14592447}; Single-pass type II membrane protein {ECO:0000269PubMed:14592447}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0010977	negative regulation of neuron projection development
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome