InnateDB Protein
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IDBP-176446.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Timm13
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Protein Name
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translocase of inner mitochondrial membrane 13 homolog (yeast)
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Synonyms
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D10Ertd378e; Tim9; Timm9;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020440
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InnateDB Gene
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IDBG-176444 (Timm13)
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Protein Structure
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Function |
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Present at high level in liver and brain, and at lower level in muscle and heart. In CNS sections, it is predominantly present in the soma and the dendritic portion of the Purkinje cells of the cerebellum, but not in the glial cells. Scattered expression also is also detected in the brain stem, olfactory bulb, substantia nigra, hippocampus and striatum (at protein level). {ECO:0000269PubMed:15254020}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
25 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1353432
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InterPro |
IPR004217
Tim10/DDP family zinc finger
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PFAM |
PF02953
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62075
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PhosphoSite |
PhosphoSite-P62075
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
30055
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UniGene |
Mm.142132
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RefSeq |
NP_038923
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MGI ID |
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MGI Symbol |
Timm13
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OMIM |
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CCDS |
CCDS35989
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HPRD |
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IMGT |
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EMBL |
AF144702
AK003054
AK009041
AK009152
AK013230
AK088984
BC011436
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GenPept |
AAD39953
AAH11436
BAB22536
BAB26042
BAB26109
BAB28728
BAC40687
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