InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttll3

Summary

InnateDB Protein

IDBP-176524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttll3

Protein Name

tubulin tyrosine ligase-like family, member 3

Synonyms

4833441J24Rik; AI450050;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032414

InnateDB Gene

IDBG-176516 (Ttll3)

Protein Structure

UniProt Annotation

Function

Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. {ECO:0000269PubMed:19524510}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305PubMed:19524510}. Cell projection, cilium {ECO:0000305PubMed:19524510}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305PubMed:19524510}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain and testis. {ECO:0000269PubMed:17499049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0070735	protein-glycine ligase activity
GO:0070736	protein-glycine ligase activity, initiating

Biological Process

GO:0006464	cellular protein modification process
GO:0018094	protein polyglycylation
GO:0035082	axoneme assembly
GO:0042384	cilium assembly

Cellular Component

GO:0005874	microtubule
GO:0005929	cilium
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2141418

InterPro

IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase

PFAM

PF03133

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A4Q9E5

PhosphoSite

PhosphoSite-A4Q9E5

TrEMBL

UniProt Splice Variant

Entrez Gene

101100

UniGene

Mm.471282

RefSeq

NP_598684

MGI ID

MGI Symbol

Ttll3

OMIM

CCDS

CCDS39593

HPRD

IMGT

EMBL

AK029462 AK080321 AM690746 BC021404

GenPept

AAH21404 BAC26459 BAC37878 CAM84323