InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nefm

Summary

InnateDB Protein

IDBP-176545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nefm

Protein Name

neurofilament, medium polypeptide

Synonyms

Nef3; NF-M; NF160; NF165; Nfm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022638

InnateDB Gene

IDBG-176543 (Nefm)

Protein Structure

UniProt Annotation

Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0008088	axon cargo transport
GO:0031133	regulation of axon diameter
GO:0045104	intermediate filament cytoskeleton organization
GO:0045110	intermediate filament bundle assembly
GO:0060052	neurofilament cytoskeleton organization

Cellular Component

GO:0005882	intermediate filament
GO:0005883	neurofilament
GO:0030424	axon
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0097418	neurofibrillary tangle