InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smndc1

Summary

InnateDB Protein

IDBP-176593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smndc1

Protein Name

survival motor neuron domain containing 1

Synonyms

2410004J23Rik; 4933440I19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025997

InnateDB Gene

IDBG-176591 (Smndc1)

Protein Structure

UniProt Annotation

Function

Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0006915	apoptotic process
GO:0008150	biological_process
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0045111	intermediate filament cytoskeleton