Version 5.4
Mus musculus Protein: Chrdl1
Summary
InnateDB Protein IDBP-176723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrdl1
Protein Name chordin-like 1
Synonyms CHL; CHL1; Nrln1; VOPT;
Species Mus musculus
Ensembl Protein ENSMUSP00000056193
InnateDB Gene IDBG-176721 (Chrdl1)
Protein Structure
UniProt Annotation
Function Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in heart, brain, lung, liver, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001503 ossification
GO:0001654 eye development
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0030514 negative regulation of BMP signaling pathway
GO:0048749 compound eye development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1933172
InterPro IPR001007 von Willebrand factor, type C
PFAM PF00093
PRINTS
PIRSF
SMART SM00214
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920C1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 83453
UniGene Mm.485673
RefSeq
MGI ID
MGI Symbol Chrdl1
OMIM
CCDS CCDS53208
HPRD
IMGT
EMBL AF296451 AF305714 AF321853
GenPept AAG27460 AAK71523 AAK95586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca