Version 5.4
Mus musculus Protein: Acp6
Summary
InnateDB Protein IDBP-176742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acp6
Protein Name acid phosphatase 6, lysophosphatidic
Synonyms 5730559A09Rik; ACPL1; AU022842; mPACPL1;
Species Mus musculus
Ensembl Protein ENSMUSP00000088263
InnateDB Gene IDBG-176740 (Acp6)
Protein Structure
UniProt Annotation
Function Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
GO:0052642 lysophosphatidic acid phosphatase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0016311 dephosphorylation
GO:2001311 lysobisphosphatidic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1931010
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily
PFAM PF00328
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BP40
PhosphoSite PhosphoSite-Q8BP40
TrEMBL
UniProt Splice Variant
Entrez Gene 66659
UniGene
RefSeq NP_062774
MGI ID
MGI Symbol Acp6
OMIM
CCDS CCDS17653
HPRD
IMGT
EMBL AB030038 AF216223 AK077729 AK089736 AK160271 AK165356 AK171757 BC047276
GenPept AAF20010 AAH47276 BAA94308 BAC36983 BAC40949 BAE35722 BAE38147 BAE42654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca