InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adamts20

Summary

InnateDB Protein

IDBP-176929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts20

Protein Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036330

InnateDB Gene

IDBG-176927 (Adamts20)

Protein Structure

UniProt Annotation

Function

May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Note=Defects in Adamts20 are the cause of the belted (bt) phenotype. It is a pigmental defect which occurs as a result of a defect in melanocyte development. {ECO:0000269PubMed:12925592}.

Tissue Specificity

Expressed at low level in testis and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0009967	positive regulation of signal transduction
GO:0030198	extracellular matrix organization
GO:0043066	negative regulation of apoptotic process
GO:0045636	positive regulation of melanocyte differentiation
GO:0048070	regulation of developmental pigmentation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:2660628

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR012314 Peptidase M12B, GON-ADAMTSs
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08685

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt