Version 5.4
Mus musculus Protein: Capn6
Summary
InnateDB Protein IDBP-176943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn6
Protein Name calpain 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000084573
InnateDB Gene IDBG-176941 (Capn6)
Protein Structure
UniProt Annotation
Function Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. {ECO:0000269PubMed:17210638, ECO:0000269PubMed:21406564}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:17210638, ECO:0000269PubMed:20814968}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0006508 proteolysis
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1100850
InterPro IPR000008 C2 domain
IPR001300 Peptidase C2, calpain, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family
PFAM PF00168
PF00648
PF01067
PRINTS PR00360
PR00704
PIRSF
SMART SM00239
SM00230
SM00720
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35646
PhosphoSite PhosphoSite-O35646
TrEMBL
UniProt Splice Variant
Entrez Gene 12338
UniGene Mm.30290
RefSeq NP_031629
MGI ID
MGI Symbol Capn6
OMIM
CCDS CCDS30455
HPRD
IMGT
EMBL AK145116 BX530055 Y12582
GenPept BAE26243 CAA73161 CAM25088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca