Version 5.4
Mus musculus Protein: Ptplad1
Summary
InnateDB Protein IDBP-176961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptplad1
Protein Name protein tyrosine phosphatase-like A domain containing 1
Synonyms 4930523M17Rik; AW742319; B-ind1; HACD3; Hspc121;
Species Mus musculus
Ensembl Protein ENSMUSP00000044955
InnateDB Gene IDBG-176959 (Ptplad1)
Protein Structure
UniProt Annotation
Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0007266 Rho protein signal transduction
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1889341
InterPro IPR007052 CS domain
IPR007482 Protein-tyrosine phosphatase-like, PTPLA
IPR008978 HSP20-like chaperone
PFAM PF04969
PF04387
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K2C9
PhosphoSite PhosphoSite-Q8K2C9
TrEMBL
UniProt Splice Variant
Entrez Gene 57874
UniGene Mm.478475
RefSeq NP_067320
MGI ID
MGI Symbol Ptplad1
OMIM
CCDS CCDS23284
HPRD
IMGT
EMBL AK050556 AK051735 AK052865 AK159494 BC031755 BC057023 Z97207
GenPept AAH31755 AAH57023 BAC34744 BAC35179 BAE20677 BAE35128 CAB10097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca